She often worked in the evenings, sitting on the floor, and painted the original artwork across the entire width of a canvas. Nature was an endless source of material, and sometimes she even used real plants for her designs. She composed the Kivet fabric, a print resembling giant stones, from circles cut out of colored paper.
When Armi Ratia banned flower patterns at Marimekko, Isola rebelled and painted a complete collection of graphic, pop-art-inspired floral fabrics. Among them was Unikko (1964), which has been continuously printed since its launch.